ImmuOligo MBG® is a carbohydrate polymer derived from the mycelium of Ganoderma lucidum, built from chains of D-glucose units linked by β-glycosydic linkages. Research has demonstrated that this unique polymer effectively supports wellness and productivity by maintaining a healthy, robust and balanced immune response without over-stimulating it.
ImmuOligo MBG® – Mode of Action
Beta glucan is known as the biological response modifiers (BRM), which refers to the ability to up-regulate and down-regulate the response of biological systems. The results of clinical research indicate that the presence of beta glucan glucopolysaccharide is linked to the production and activation of macrophages, NK-cells, T-cells, B-cells from the body’s natural defense system. This is accomplished by a cascade of biological reactions triggered by the binding of the beta glucan molecules to the Dectin-1/CR3 receptors presented on cells.
It has been shown that the use of ImmuOligo MBG can help adjusting innate and adaptive defense mechanism, and therefore promote a well-balanced Th1 and Th2 response, suited to the seasonal challenges.
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Chae, B.J., Lohakare, J.D., Moon, W.K., Lee, S.L., Park, Y.H., Hahn, T.W., 2006. Effects of supplementation of beta-glucan on the growth performance and immunity in broilers. Res Vet Sci. 80(3):291-298.
Chen, S.D., Hsieh, M.C., Chiou, M.T., Lai, Y.S., Cheng, Y.H., 2008. Effects of fermentation products of Ganoderma lucidum on growth performance and immunocompetence in weanling pigs. Arch Anim Nutr. 62(1):22-32.
Cox, C.M., Sumners, L.H., Kim, S., McElroy, A.P., Bedford, M.R., Dalloul, R.A., 2010a. Immune responses to dietary beta-glucan in broiler chicks during an Eimeria challenge. Poult Sci. 89(12):2597-2607.
Cox, C.M., Stuard, L.H., Kim, S., McElroy, A.P., Bedford, M.R., Dalloul, R.A., 2010b. Performance and immune responses to dietary beta-glucan in broiler chicks. Poult Sci. 89(9):1924-1933.
Wu Y-S, Chen S, Wang W, Lu C-L, Liu C-F, Chen S-N. Oral Administration of MBG to Modulate Immune Responses and Suppress OVA-Sensitized Allergy in a Murine Model. Evidence-based Complementary and Alternative Medicine. 2014:567427.